McTeague is a simple dentist who becomes infatuated with Trina, the cousin of his friend Marcus. Trina then buys a winning lottery ticket worth $5,000, and McTeague announces his plans to marry her. But their marriage quickly falls apart as greed consumes them both, and Marcus' jealousy toward McTeague boils over.

Vandover is a student who succumbs to a gambling addiction. This addiction causes him to divest himself of his cherished possessions and to lose his status in life, whilst his friends prosper. Eventually he is transformed by a strange degenerative lycanthropy, reduced to running back and forth across his apartment, naked, on all-fours. The novel was Norris' first, though published posthumously. Characteristically, it explores the themes of habit and addiction in a heightened "naturalistic" style.

Frank Norris based his 1901 novel The Octopus (A Story of California) on the Mussel Slough Tragedy of 1880, a bloody conflict between ranchers and agents of the Southern Pacific Railroad. The central issue was over the ownership of the ranches, which the farmers had leased from the railroad nearly ten years earlier with intentions of eventually purchasing the land. Although originally priced at $2.50 to $5 per acre, the railroad eventually opened the land for sale at prices adjusted for land improvements; the railroad’s attempts to take possession of the land led the ranchers to defend themselves as depicted in the book.